Taking place at The Baker's Vault in Stockport, the event will feature an as yet unnamed line up of "three of the best from the North West's comedy circuit."
36 editorial jobs have now been lost across the weekly newspaper group through Manchester, Cheshire and Lancashire.
Jenny Lennox of the NUJ commented: "There has been a massive attack on local journalism in Stockport and Greater Manchester, which has removed journalists from the communities they serve.
"We are delighted to see that people are prepared to stand up for journalism and show how much it matters."
The gig follows on from "the fantastic success" of a similar event in London in April.
Tickets cost £5 and are available from the NUJ office on 0161 237 5020.
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